Human Endogenous Retroviruses as Pathogenic Factors in the Development of Schizophrenia
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چکیده
منابع مشابه
Human Endogenous Retroviruses as Pathogenic Factors in the Development of Schizophrenia
Schizophrenia is a complex disorder, characterized by the interplay between genetic and environmental factors. Human endogenous retroviruses (HERVs), genetic elements that originated from infections by exogenous retroviruses millions of years ago, comprise ~8% of the human genome. Here, we provide a comprehensive review of accumulating evidence, detailing HERV aberrancies associated with schizo...
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Mammalian genomes include a considerable number of endogenous retroviruses (ERVs), relics of ancestral infectious retroviruses, whose proviruses have invaded the germ-line. The documented ability of infectious retroviruses to cause cancer has greatly contributed to the discovery of ERVs. It also reinforced the concept that ERVs are causative agents of many cancers, a notion that historically ha...
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Human endogenous retroviruses (HERVs) represent footprints of previous retroviral infections. They are integrated within the human germ line and constitute approximately 8% of our genome. They have the potential to harm, given their capacity to alter the cellular metabolism, and could be involved in various pathological processes. This revision intends to highlight the importance of HERVs in he...
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ژورنال
عنوان ژورنال: Frontiers in Psychiatry
سال: 2016
ISSN: 1664-0640
DOI: 10.3389/fpsyt.2015.00183